Eh.  Though this is a bad idea, I do not blame a company trying to make money on a niche market.  IMO it is kind of like Nintendo making Nintendogs a few years back and was so successful, there are all sorts of virtual pet games.  Sure the concept is not exactly new, but the delivery in that medium just worked. 

If you are a female and have less than zero interest in games like this, then you are not the market they are going for.  My wife has a diverse interest in games as well, although she has fallen victim to accessories aimed at girls with things like an Xbox 360 controller, Nintendo DS, and Wiimote sleeve...ALL PINK!  lol   She is not into FPS's so much, but she has been caught up in the action/drama that is MGS4 and GTA4.  We are also avid SingStar, Rockband, and Guitar Hero players among other things.  Basically, if it is fun, it will be played.  Even if there is no lead like the recent release of a crossword game on Xbox Live. 

Grifter - That second link is not 2006 to present.  Parasite Eve (AWESOME game) came out in '98, and Super Metroid was out on the SNES in the mid 90's sometime.  Also, on the first 'Link' (see what I did there), Princess Zelda is not such a strong female lead.  She always gets kidnapped and has to be rescued by Link.  The only time she is tough is in the Super Smash Bros. games, but in those she is not a lead character.  Both were also missing Heavenly Sword in which the lead is a gal named Nariko who totally kicks butt. 

To me, the gender of the lead character does not sway me in my game playing choice.  And in all honesty, I choose a female character when given the choice MOST of the time, especially in an MMORPG, haha.

Lastly, when you said, "Although if they ever do decide to make a game where we get to shoot up Lindsay Lohan, then we're talking" I didn't know if you meant with a gun or syringe.  :-P

Now you're talking, Billy. LOL. Perhaps they could make a whole series of video games starring young celebs. Maybe one where you play Britney Spears' manager and have to keep her from destroying her career.

Do not get me started on the absurdity of "girlie" games. I have the video game skills of a blind monkey, but when I do decide to play a game [something that amuses my brother greatly], I play the blow 'em up, shoot 'em up games because they actually require skills and you know, the ability to think and make decisions. Even my daughter likes the games with action. She was even upset with me cause I wouldn't let her play Grand Theft Auto cause "it looks so cool." Um, no. 
The very idea of video games based on anything to do with Clueless or Pretty in Pink infuriates me to no end. What next? A video game about childbirth? How about cervical cancer? Ooh, I've got it. How about a game where you get to try to put on fake eyelashes while driving down the road? You want to gear games toward girls, there ya go. Grrrr

http://www.shinyshiny.tv/2007/04/top_... one just may tick you off even further

http://sandradodd.com/game/female this one contains a list of games with female leads from kid friendly to adult teen (would that be an oxymoron?) but dates back to 2006
There is also not a lot of ethnic diversity in video games when it comes to the hero
I googled video games with female leads but I can not view all sights since I am at work

You could make a really fun Lindsay Lohan game. You'd have drugs, car chases and mini-games like not setting off the alcohol monitor or remember lines for "Georgia Rule."